Product Search


Study Finds Variant Of Gene That Ups Predisposition To Bipolar Schizophrenia


Bipolar disorder and schizophrenia are two of the most common severe mental illnesses, causes of which still not known well. However, new developments regarding the origins of the diseases and how they cause a metamorphosis in an individual keep coming to light. A recent study concludes that a genetic variant - synaptosomal associated protein (SNAP25) - is responsible for increasing an individual's risk for developing these diseases.


According to study author Stephane Jamain, a promoter variant of SNAP25 - rs6039769 - is associated with the early onset of bipolar disorder and is also responsible for "higher gene expression level in human prefrontal cortex." A gene has several control sites that are involved in the process of transcription, including the start site, the promoter, enhancers and silencers that function similar to the name.


Variant associated with larger amygdala volume


The researchers used genetic analysis and neuroimaging in samples of adults with schizophrenia and traces of starting symptoms of bipolar disorder along with postmortem analysis of brain tissues from schizophrenia patients. They compared these with those of the control group and found that the SNAP25b: SNAP25a ratio was higher in schizophrenic patients who had the rs6039769 at-risk allele (alternative forms). The study also used genetic imaging and revealed that "male risk carriers had an increased amygdala-ventromedial prefrontal cortex functional connectivity and a larger amygdala than non-risk carriers." The genetic mutation was responsible for the way the SNAP25 protein was expressed in the brain, which could affect the way information was processed between the brain regions involved in regulating emotions.


Larger amygdala volume has been implicated for bipolar disorder in past studies as well. The amygdala dons several roles from spurring the fight-or-flight mechanism to emotional control and regulation. It connects with the ventral prefrontal cortex (VPFC), responsible for modulating responses related to external emotional cues and inner stimuli. Lack of connectivity between the VPFC and the amygdala makes an individual feel anxious and stressful even in day-to-day situations as a result of "emotion homeostasis." Elucidating on this link, a review article by Stephen Strakowski of the University of Cincinnati said, " Effectively, with diminished prefrontal modulation, the limbic brain is hypothesized to be dysregulated, leading to the emotional extremes of mania, depression, and mixed states."


Timely diagnosis vital to productive life


According to the National Institute of Mental Health (NIMH), people suffering from bipolar disorder undergo unusually intense emotional states during distinct periods called mood episodes. Each mood episode represents a drastic change from a person's usual mood and behavior. An overly joyful or overexcited state is called a manic episode, and an extremely sad or hopeless state is called a depressive episode. Increased activity levels can be followed by long periods of depression.


Timely recognition of mental health disorders is extremely important to help a person lead a healthy and productive life. It therefore becomes vital to rely only on a qualified doctor or psychiatrist for medications. Self-medication and substance abuse to mitigate the effects can make the problem worse. Some medications like antidepressants are known to increase the risks of mania in patients who are already susceptible to developing bipolar disorder.



Featured Products






Articles


Hyundai Grand I10 A Little Bit Of Style And Lot More Substance
Outdoor Fire Pit Grilling For The Big Game
So You Plainly Received An Adorable
Computer Amc A Profitable Deal For Companies
What Are The Advantages Of Yard Vacuums
Beverage Air Might Be The Solution For You
Change The Ringtone On An Iphone
5 Amazing Ways To Accentuate The Look Of The Space Through Bar Chairs
Grab The Best Children Toys In Uae At Attractive Prices Online
How To Chose The Best Flea Killer For Dogs
Discover How Use Your Home With Abstract Wall Art
Stainless Steel Fridges A Sharp Look For Your Kitchen
Top of The List Costa Rica Luxury Homes For Sale
An In Depth Look At Digging Tools Let S Get Digging
Weighing The Pros And Cons Of Setting Up A Business In Finland
Can You Imagine Life Without Tools
Home Renovation Trends Extensions
Stop And Think Before Buying Your Teen A Car
Remove Tensions Installing Tensile Structures In Outdoors
Anything for Chocolate Birthday Cake
Three Outstanding Benefits of Prefab Homes
Know About Outdoor Patio Furniture
Sportswear Facilitates Comfort And Better Performance
The Top Selling Online Accessory Handbags
Enhance Phone With Cell Phone Cases
The Best Ways To Discover A Garden Sheds
Best Buys For Books at Bestbuyingbooks
Online Shopping Stores Have Made It Time Savvy For Customers To Buy Dresses Online
Sofas Inevitable Part Of Decoration
Issue 6 24 Best Ways To Do The Things That Matter
Top 3 Benefits of Water Fountains in Your House And Offices
Leather Sleeper Sofas Review And Buying Guide
Dynamics Gp Ap Historical Trial Balance Recreation In Crystal Report
Furnish Your Table With Top Quality Miami Restaurant Supplies
Have Great Riding Experience Throughout Selection Of Highly Featured Fixed Gear Bikes
Modern Innovative Design With Chandelier Table Lamps
It Had Antilock Fourwheel Disc Brakes
Fender Mustang I Guitar Amplifier Review
Gourmet Coffee Beans My Odyssey Into The World Of Coffee Beans That Truly Taste Divine
An Overview Of Fly Fishing Equipments
What to Avoid When Sealing a Deal With Kit Homes Contractors in Perth
Game Tester
Find Homes For Sale Lehi
What Beginner Cooks Need to Know Related to Cooking With Tagine
How Do Money Market Accounts Work
Looking For The Best Formal Dresses Brisbane
How To Choose A Ladder Rack For Your Work Van
The Importance Of Buying Branded Women S Insoles For Shoes
Korean Corn Dogs - Video
Pendant Lighting Everything You Need To Know